Use of rhDNase pulmozyme

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Norfolk Suffolk Cambridge Cystic Fibrosis Netwirk Guideline.  

Recombinant human deoxyribonuclease rhDNase Pulmozyme® is a synthetic enzyme that cleaves neutrophil-derived deoxyribonucleic acid DNA in sputum to reduce viscosity and thus in theory to aid sputum removal. Studies demonstrate a 5-8% overall improvement in forced expiratory volume in one second FEV1 but this masks a wide response range from deterioration to marked improvement 20%+ .

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Date Uploaded
08.09.2015
Date Review
04.09.2017
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103Kb