Diabetes Related in Children with Cystic Fibrosis

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Norfolk Suffolk Cambridge Cystic Fibrosis Network Guideline.   

The prevalence of CFRD rises with increasing age of survival with the median age of onset at 21years [range 3-40 years] 1. It is more prevalent in patients with exocrine pancreatic deficiency and as such can be correlated to genotype 20% of subjects with class I – III mutations vs 1.5% of subjects with class IV-V mutations 2. There is however no association with positive family history or HLA class II blood group gene3. CFRD is a distinct type of diabetes WHO/NCD/NCS/99.2 with features of both Type 1 and Type 2 diabetes. However there are important differences due to glucose metabolism in CF being affected by infective respiratory status increased basal metabolic rate malnutrition and gastrointestinal abnormalities

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Date Uploaded
17.07.2015
Date Review
17.07.2018
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140Kb